RLE Group
Extend Life radically

RLE Group is a Spain-based non-profit organisation with a mission to develop bioengineering solutions for healthy life extension. Founded by the scientist who proposed the 10th hallmark of aging and a group of biohackers known for their experiment to translate therapeutic plasma exchange on human beings.

Longevity gene delivery system

Safe and efficient gene delivery system based on a non-viral vector and silicon nanoparticles for gene therapy of aging. With the help of this system we could deliver a combination of several genes each of which extended lifespan of mice by up to 40%.
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Epigenetic Rejuvenation

We developed a compound only several injections of which are capable of extending a lifespan of already aged mice by more than 10% by rejuvenating epigenetic signature of aged blood stems cells.
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Restoration of Elastin

We are developing a genetic vector carrying all genes that are necessary for elastogenesis. This vector in conjunction with our gene delivery system will help to return elasticity to aged skin and potentially could be used to restore elasticity of other organs and tissues like heart, lungs and blood vessels.
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Core Members of the RLE group

Alexander Fedintsev, MSc
CSO

Yury Khait, MSc
CEO

Dmitrii Sosin, PhD
Principal Research Scientist

Stanislav Polozov, MSc
Director, Intellectual Property

Andrei Isaev, MD
Investor, Board Member

Nikolai Sidorov
Investor, Board Member

Aleksei Moskalev, PhD
Biogerontologist with 20+ years experience in Ageing Research

Ellen Segal
Honorary Professor

Alice Perekopskaya
Sponsorship Manager

Scientific Publications

Stochastic non-enzymatic modification of long-lived macromolecules - A missing hallmark of aging.

Ageing Research Reviews
Sep, 2020
11.788 Impact Factor

Markers of arterial health could serve as accurate non-invasive predictors of human biological and chronological age.

Aging (Albany NY), 9(4), 1280
Apr, 2017
5.955 Impact Factor

Developing criteria for evaluation of geroprotectors as a key stage toward translation to the clinic.

Aging cell, 15(3), 407-415
Mar, 2016
11.005 Impact Factor

The influence of pro-longevity gene Gclc overexpression on the age-dependent changes in Drosophila transcriptome and biological functions.

BMC genomics
Dec, 2016
4.931 (2021) 5 year impact factor

Circadian clock genes' overexpression in Drosophila alters diet impact on lifespan.

Biogerontology
Apr, 2019
5.585 (2021) 5 year impact factor

The Resistance of Drosophila melanogaster to Oxidative, Genotoxic, Proteotoxic, Osmotic Stress, Infection, and Starvation Depends on Age According to the Stress Factor.

Antioxidants
Dec, 2020
7.886 (2021) 5 year impact factor

Media about us

ONE OF THE MAIN CAUSES OF AGING

A recent article in "Fortune" magazine about the prospects for overcoming aging refers, among others, to the work of our CSO A.Fedintsev, where he proposes the 10th hallmark of aging and claims that damage to long-lived proteins of the extracellular matrix may be a key driver of aging.
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BIOHACKING - A NECESSARY COMPONENT OF A STRATEGY FOR RADICAL LIFE EXTENSION

Our CSO A.Fedintsev at Foresight Institute talks about biohacking and why it is an important component of a strategy for radical life extension.
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PLASMA DILUTION EXPERIMENT ON HUMANS

Our team was the first to try therapeutic plasma exchange on humans. We tried it on ourselves, measured various biomarkers and noticed some positive changes. More details are in the article.
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OUT FOR BLOOD IN THE SEARCH TO STALL AGING

Another article about our experiment of translating therapeutic plasma exchange from mice to humans.
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Spotlight: Rising Star Award at Longevity Summit 2024

Measuring and Treating Clonal Hematopoiesis - Alexander Fedintsev at Longevity Summit Dublin 2024

Aleksandr Fedintsev, a rising star in longevity research, was honored with the prestigious Rising Star Award presented by the renowned Aubrey de Grey. This recognition highlights Aleksandr Fedintsev's innovative contributions to the field of aging research.In his keynote speech, de Grey praised Fedintsev's groundbreaking vision of aging processes, noting that it has significantly influenced his own perspective. Fedintsev's work focuses on the alteration of the extracellular matrix as a fundamental cause of aging, utilizing advanced mathematical modeling techniques to gain new insights.This award not only celebrates Fedintsev's achievements but also underscores the rapid advancements and fresh perspectives emerging in longevity science. It's inspiring to see new researchers making such impactful contributions to our understanding of aging and potential interventions for extending healthspan.

RLE Group Extend Life radically

Longevity gene delivery system

Epigenetic Rejuvenation

Restoration of Elastin

Core Members of the RLE group

Alexander Fedintsev, MScCSO

Yury Khait, MScCEO

Dmitrii Sosin, PhDPrincipal Research Scientist

Stanislav Polozov, MScDirector, Intellectual Property

Andrei Isaev, MDInvestor, Board Member

Nikolai SidorovInvestor, Board Member

Aleksei Moskalev, PhDBiogerontologist with 20+ years experience in Ageing Research

Ellen SegalHonorary Professor

Alice PerekopskayaSponsorship Manager